okjiujiu99

为方便大家掌握本领域的知识，特设立本帖收集本领域优秀的review的全文。本帖不得讨论其他内容
要求：推荐文献，原则上应该是最近5年内影响因子5以上期刊发表的review，而且本人已经阅读感觉质量很高。特殊情况请说明。
格式要求：
1）题录：
要求为pubmed的summary格式，
例如：
Quesenberry PJ, Colvin G, Dooner G, Dooner M, Aliotta JM, Johnson K.        
The stem cell continuum: cell cycle, injury, and phenotype lability.
Ann N Y Acad Sci. 2007 Jun;1106:20-9. Epub 2007 Mar 14. Review.
PMID: 17360803
2）推荐理由：
3）全文：

评分说明：推荐文献之前，请先查看是否已经有战友发布了；每推荐一篇文献，给予50cells奖励，累计最高奖励400cells；如版主审阅不符合要求，或者重复可不给予评分，存在恶意行为者给予扣分；
版主会定期将战友推荐的review题目和全文链接整理并发布在1楼和2楼。谢谢大家支持！

[ 本帖最后由 okjiujiu99 于 2007-10-5 23:44 编辑 ]

okjiujiu99

占用

okjiujiu99

占用

okjiujiu99

(1)Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis
Stingl J, Caldas C.
Nat Rev Cancer. 2007 Oct;7(10):791-9.
Human breast cancers are heterogeneous, both in their pathology and in their molecular profiles. This suggests the hypothesis that breast cancers can initiate in different cell types, either breast epithelial stem cells or their progeny (transit amplifying cells or committed differentiated cells). In this respect, breast cancer could be viewed as being similar to haematological malignancies for which an analogous model has been proposed. Drawing such parallels might help to unravel the molecular nature of the initiating events in breast cancer and might have substantial clinical implications
(2)结合癌干细胞理论，从分子标记物来分析乳腺癌的各种亚型异质化。建议用研究白血病各种亚型的基因和分子差异的方法来研究乳腺癌的各种亚型，以求找到各种亚型癌干细胞的差异，应用于临床。
（3）附上全文。

[ 本帖最后由 okjiujiu99 于 2007-10-8 18:41 编辑 ]

goldideas

我来：
1）Reya T, Morrison SJ, Clarke MF, Weissman IL.       
Stem cells, cancer, and cancer stem cells.
Nature. 2001 Nov 1;414(6859):105-11. Review.
PMID: 11689955
2）这篇文章在肿瘤干细胞从实体肿瘤分离出来之前，即推测肿瘤干细胞的存在。属于经典文章，引用次数>500.
3）全文链接如下：

goldideas

1。Pardal R, Clarke MF, Morrison SJ.       
Applying the principles of stem-cell biology to cancer.
Nat Rev Cancer. 2003 Dec;3(12):895-902.
PMID: 14737120
2。这篇是刚刚从实体瘤分离成功时的文章，虽然上一篇有点古老了，但是这两篇文章，均是肿瘤干细胞文献的必引文章。
3。全文如下

lgf198

也想贴个附件给大家，就是不知道怎么贴

点击帖子右下方的回复按钮就可以看到上传附件的选项了

[ 本帖最后由 llecmets 于 2007-10-12 15:22 编辑 ]

天是蓝的

1）题录：
Dalerba, P., R. W. Cho, et al. (2007).
"Cancer stem cells: models and concepts."
Annu Rev Med 58: 267-84.
PMID: 17002552
2）推荐理由：看杂志名就知道值得一看。
3）全文：在附件

[ 本帖最后由 天是蓝的 于 2007-10-12 14:23 编辑 ]

okjiujiu99

1 题录
“Destemming” Cancer Stem Cells
Richard P . Hill , Roberto Perris
J Natl Cancer Inst 2007;99: 1435 – 40
abstract:Cancer stem cells have been variously defined as cells within a cancer that have the exclusive ability to self-renew and to differentiate into the heterogeneous lineages of cancer cells that comprise the tumor. Interest in cancer stem cells is currently high, arising from recent reports identifying cell surface markers that can be used to sort such cells from primary human tumors. However, use of the term cancer stem cell may be misleading. A better term might be cancer-initiating cells because it remains to be demonstrated that cancer stem cells have the properties that define normal stem cells, including multipotency and the ability to undergo asymmetric and symmetric divisions. Many properties of cancer stem cells remain unclear, particularly the stability of their phenotype. These uncertainties must be considered in the development and testing of compounds targeted against putative cancer stem cells. Tumors apparently contain very few cancer stem cells, so that when tests of compounds targeted to such cells are designed, short-term response trials may not be informative and long-term trials must be planned, particularly if the drugs could also kill normal stem cells.
提纲：（1）Traits of Normal Stem Cells and Cancer Stem Cells
     （2）Relationship Between Normal Stem or Progenitor Cells and Cancer-Initiating Cells
     （3）Reliability of the Current Markers and Isolation Protocols for Cancer Stem Cells
     （4）Conclusions and Comments About Testing Novel Therapeutic Approaches
2 推荐理由
红色的就是作者的主要观点吧，肿瘤干细胞很热，目前的验证方式主要还是通过表面标记物来确定，然后检测自我跟新、分化和致瘤能力。但是都是短期的结果，真正的干细胞要经过长期的验证。比如干细胞的对称和非对称分裂方式，长期药物实验，这样文献报道的几乎没有。所以验证肿瘤干细胞的存在和功能，还需要在结构、功能方面长期的实验。
3 附上全文。

eidolon

谢谢LZ分享！！

eidolon

下不了啊，郁闷！！

请先进新手学习版，了解如何获取cell
http://bbs.stemness.net/forum-17-1.html

[ 本帖最后由 llecmets 于 2007-10-26 11:04 编辑 ]

阿里巴巴

上传一篇
ABSTRACT:The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This reviewprovides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day. We present the concept of a
cancer stem cell, and review for you the literature supporting the existence of cancer stem cells in addition to a brief discussion on our own work supporting a bone marrow-derived source for the cancer stem cell, as well as cells of the cancer stroma.

风落无尘

我也来一篇
1）题录：
"The Biology of Cancer Stem Cells."
Neethan A. Lobo, Yohei Shimono, Dalong Qian, Michael F. Clarke

Annu. Rev. Cell Dev. Biol. 2007.23:675-699
Contents
INTRODUCTION. . . . . . . . . . . . . . . . . 676
RELATIONSHIP BETWEEN
NORMAL AND CANCER
STEM CELLS. . . . . . . . . . . . . . . . . . . 677
Defining Properties of Normal
Stem Cells . . . . . . . . . . . . . . . . . . . . 677
Theory of Cancer Stem Cells . . . . . 678
Early History of Tumorigenic
Stem Cells . . . . . . . . . . . . . . . . . . . . 680
PROSPECTIVE ISOLATION OF
CANCER STEM CELLS . . . . . . . . 681
Cellular Origin of Cancer Stem
Cells . . . . . . . . . . . . . . . . . . . . . . . . . . 683
SOLID TUMOR STEM CELLS:
TUMOR STEM CELLS IN THE
CENTRAL NERVOUS
SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . 685
Cancer Stem Cells in Other
Tissues . . . . . . . . . . . . . . . . . . . . . . . 687
SIGNALING PATHWAYS IN
CANCER STEM CELL
BIOLOGY. . . . . . . . . . . . . . . . . . . . . . . 688
Master Control Signaling
Pathways that Regulate Cancer
Stem Cell Functions . . . . . . . . . . . 688
Other Functional Pathways Affect
Cancer Stem Cell Behavior . . . . 690
CLINICAL IMPLICATIONS OF
CANCER STEM CELLS . . . . . . . . 691
CONCLUSIONS. . . . . . . . . . . . . . . . . . . 692

2）推荐理由：很全面，值得一看
3）全文：在附件


[ 本帖最后由 风落无尘 于 2007-11-6 23:47 编辑 ]

alphazeta

一篇06年新英格兰医学上关于CSCs的综述
1）题录：
Jordan CT, Guzman ML, Noble M.
Cancer stem cells
N Engl J Med. 2006 Sep 21;355(12):1253-61.
PMID:16990388
2）推荐理由：众所周知，新英格兰医学是偏重于临床的杂志，因此文章除了介绍CSCs基础，血液系统，中枢神经系统和乳腺癌中CSCs的研究现状，还在最后阐明了临床靶向CSCs治疗可能存在的挑战。
3）全文：

alphazeta

06年9月AACR上对于CSCs研究现状的概括和前景展望。
1）题录：
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM.
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells
Cancer Res. 2006 Oct 1;66(19):9339-44. Epub 2006 Sep 21.
PMID:16990346
2）推荐理由：这篇综述（或者说会议记录）很好的对目前CSCs的研究现状和研究前景进行了讨论，作者各个都是CSCs领域的大牛，个人觉得非常的重要，不可不看。
3）全文：