abaddoctor

Chinese Journal of Cell Biology 2007，29：202—206

Cell, Vol. 91, 661–672, November 28, 1997；
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

MLL translocations, histone modifications and leukaemia stem-cell development。www.nature.com/reviews/cancer

[ 本帖最后由 jfzeng 于 2008-3-20 00:26 编辑 ]

未至三十期

果然是人多力量大，差不多都给大家搜集齐了。
今天既然来了，虽然迟到许多，赶不上给大家贡献文章，不过也顺便通知一下。多为名家大牌合力完成的集大成之权威著作、由ELSVIER出版的《Handbook of Stem Cells》已经上传到verycd，目前正在调试电驴链接，完成后会再次通知大家，请各位准备好驴子去拉吧

cyl98

题目Cancer stem cells: an old idea--a paradigm shift.

作者Wicha MS, Liu S, Dontu G.

PMID: 16488983 [PubMed - indexed for MEDLINE

推荐理由：内容充分，有见地，深入，适合新手入门

yzfdyhm

Polycomb genes encode critical regulators of both normal stem cells and cancer stem cells. A gene signature that includes Polycomb genes and additional genes coregulated with Polycomb genes was recently identified. The expression of this signature has been reported to identify tumors with the cancer stem cell phenotypes of aggressive growth, metastasis, and therapy resistance. Most members of this 11 gene signature encode proteins with well-defined roles in human cancer. However, the function of the signature member USP22 remains unknown. We report that USP22 is a previously uncharacterized subunit of the human SAGA transcriptional cofactor complex. Within SAGA, USP22 deubiquitylates histone H2B. Furthermore, USP22 is recruited to specific genes by activators such as the Myc oncoprotein, where it is required for transcription. In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle.比较新的，介绍大家看看

jfzeng

出自？

yfsq

题录：
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Visvader JE, Lindeman GJ.
Nat Rev Cancer. 2008 Sep 11. [Epub ahead of print]

推荐理由：总结当前实体瘤干细胞的研究现状，尽管我立题的参考文献不列在其中有点郁闷。

[ 本帖最后由 yfsq 于 2008-9-14 20:46 编辑 ]

luoht1985

题目Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
理由，关于肺癌肿瘤干细胞的鉴定很好的文章
Summary ：Injury models have suggested that the lung contains anatomically
and functionally distinct epithelial stem cell populations. We have isolated such a regiona。。。。。。

luoht1985

题目：The Putative Cancer Stem Cell Marker USP22 Is a
Subunit of the Human SAGA Complex Required for
Activated Transcription and Cell-Cycle Progression
1The Department of Cancer Biology, The Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, PA 19107, USA
2The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
3University of Portsmouth, Portsmouth PO1 2DT, UK
4The Wistar Institute, Philadelphia, PA 19104, USA
5These authors contributed equally to this work.
*Correspondence: steven.mcmahon@mail.jci.tju.edu
DOI 10.1016/j.molcel.2007.12.015
理由：来自费城托马斯杰弗逊大学（Thomas Jefferson University）医学院，Kimmel癌症中心（The Kimmel Cancer Center，生物谷注），宾州大学医学院，英国普茨茅斯大学（University of Portsmouth）的研究人员发现一个能预测肿瘤侵占及扩散的11基因“信号”：USP22的作用，这是理解癌症干细胞标记的一种重要成果，能帮助研究人员更深入的了解癌症干细胞基因在正常细胞中的功能，以及与基因表达的关系。
这一研究成果公布在Molecular Cell杂志上，领导这一研究的是托马斯杰弗逊大学癌症生物学副教授Steven McMahon博士。

luoht1985

题目Epigenetic stem cell signature in cancer
理由：：最近，来自USC的研究人员最近在解决一个争论了十多年的问题上取得了重大进展。这个争论的中心是：干细胞在肿瘤的发展中扮演的角色。根据此项研究发现（即将在Nature Genetics发表，现在可以在线获得），在肿瘤中始终保持静止的基因中，那些在胚胎干细胞被逆向抑制的基因过度表达。这个联系增加了对讨论越来越多的肿瘤来自小部分干细胞理论的支持。
    USC在观察了177个由PcG组蛋白抑制的基因，77个完全说明与肿瘤相关DNA修饰酶的证据（称之为甲基化）。研究人员发现，一些在胚胎干细胞中受Polycomb抑制的基因实质上被DNA甲基化提前标记为永久静止。阻止胚胎干细胞分化，那样，在生命晚期，它们就可以成为肿瘤发展的基础。USC的研究者作了与乳腺癌、结肠癌、肺癌和卵巢癌有关的观察。
USC的研究不仅为肿瘤干细胞起源学说提供了实验证据，而且也支持了肿瘤中在很早期就包含了胚胎变化的说法。研究者发现肿瘤出现在已经发生胚胎学变化的细胞中，这指出了在肿瘤发展中，实验胚胎事件在遗传事件发生之前进行。这一个相对较新的理论正在得到科学家们的支持。         
这一研究显示肿瘤起源于干细胞，，这对于监督胚胎畸变非常重要，可以防止干细胞移植应用中，人们接受有潜在致癌倾向的细胞。下一步研究人员将集中研究是什么引起一些基因从短期抑制转变成永久静止的。

xieqinfen1985

Evidence Regarding a Stem Cell Origin of Hepatocellular
Carcinoma
Thomas Shupe1 and Bryon E. Petersen*,†,1,2
1Department of Pathology, Immunology and Laboratory Medicine. University of Florida, College of Medicine,
Gainesville, FL; 2Program for Stem Cell Biology, University of Florida Shands Cancer Center, Gainesville, FL

Stem Cell Reviews

[ 本帖最后由 xieqinfen1985 于 2008-12-7 16:07 编辑 ]

nuomidemao

Laboratory Investigation (2008) 88, 459–463; doi:10.1038/labinvest.2008.14; published online 31 March 2008
The cancer stem cell hypothesis: in search of definitions, markers, and relevance
Abstract
Cancer is a disease of genes. Inherited or somatic alterations in genes are what make a normal cell ignore growth-controlling signals and form a tumor that eventually leads to the destruction of the organism. Based on accumulated knowledge on the genetic composition of cancer cells, the clonal evolution model of tumorigenesis was established, which explains multiple aspects of human disease and clinical observations. However, the recently popularized cancer stem cell hypothesis questions that all or most tumor cells can participate in tumor evolution and restricts this property to a subset of them defined as 'cancer stem cells' due to their stem cell-like characteristics. Enthusiasm surrounding this area of investigation and its presumed clinical implications led to a spurt of studies in various cancer types and model systems. Rigorous study design and critical data interpretation have to be employed to test the scientific and clinical relevance of the cancer stem cell hypothesis and its relationship to the clonal evolution model.

icanfly2011

Author:    James E. Trosko
Title:     Human Adult Stem Cells as the Target Cells for the Initiation of Carcinogenesis and for the Generation of "Cancer Stem Cells".
Location:  International Journal of Stem Cells Vol. 1, No. 1, 2008
From:      Department of Pediatrics/Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, USA


Abstract:The inference to stem cells has been found in ancient myths and the concept of stem cells has existed in the fields of plant biology, developmental biology and embryology for decades. In the field of cancer research, the stem cell theory was one of the earliest hypotheses on the origin of a cancer from a single cell. However, an opposing hypothesis had it that an adult differentiated somatic cell could "de-differentiate" to become a cancer cell. Only within the last decade, via the "cloning" of Dolly, the sheep, did the field of stem cell biology really trigger an exciting revolution in biological research. The isolation of human embryonic stem cells has created a true revolution in the life sciences that has led to the hope that these human stem cells could lead to (a) basic science understanding of gene regulation during differentiation and development; (b) stem cell therapy; (c) gene therapy via stem cells; (d) the use of stem cells for drug discovery; (e) screening for toxic effects of chemicals; and (f) understand the aging and diseases of aging processes.

Keywords: Adult stem cells, Oct-4, Initiation/promotion/progression hypothesis of carcinogenesis, Re-programming, De-differentiation theory, iPS cells, Stem cell theory of carcinogenesis

Why ?It's a good review article,I think .How about you?

[ 本帖最后由 icanfly2011 于 2008-12-16 13:19 编辑 ]

icanfly2011

ASH 50th anniversary review
Author:   John E. Dick
Title:  Stem cell concepts renew cancer research
Location: BLOOD, 15 DECEMBER 2008   VOLUME 112, NUMBER 13
From :   Division of Cell and Molecular Biology, University Health Network, and Department of Molecular Genetics, University of Toronto, Toronto, ON

Abstract:
Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the individual cells that make up the tumor exhibit considerable variation
in many properties, including morphology, proliferation kinetics, and the ability to initiate tumor growth in transplant assays. Understanding the molecular and cellular basis of this heterogeneity has important implications in the design of therapeutic strategies. The mechanistic basis of tumor heterogeneity has been
uncertain; however, there is now strong evidence that cancer is a cellular hierarchy with cancer stem cells at the apex.
This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer.

新文章 图文并茂 值得一读
作者大家可能都知道的

[ 本帖最后由 icanfly2011 于 2008-12-16 14:10 编辑 ]

dhy19770308

下载不了啊

neuron

肿瘤和凋亡是一对双胞胎，必须联系起来比较研究，下面的综述值得研读：
Critical Reviews in Oncology/Hematology 66 (2008) 42–51
Apoptosis in normal and cancer stem cells
附件怎么传啊