zhousjplasur

为方便大家掌握本领域的知识，特设立本帖收集本领域优秀的review的全文。本帖不得讨论其他内容
要求：推荐文献，原则上应该是最近5年内影响因子5以上期刊发表的review，而且本人已经阅读感觉质量很高。特殊情况请说明。
格式要求：
1）题录：
要求为pubmed的summary格式，
例如：
Quesenberry PJ, Colvin G, Dooner G, Dooner M, Aliotta JM, Johnson K.        
The stem cell continuum: cell cycle, injury, and phenotype lability.
Ann N Y Acad Sci. 2007 Jun;1106:20-9. Epub 2007 Mar 14. Review.
PMID: 17360803
2）推荐理由：(由于成体干细胞包括多种来源，故要求说明是论述哪种成体干细胞的review）格式可以如下：本篇是关于（1.bone－marrow mesenchymal stem cell or2.haematopoietic or3.adipose-derived or4.neural等等）的经典review，。。。
3）全文：

评分说明：推荐文献之前，请先查看是否已经有战友发布了；每推荐一篇文献，给予50cells奖励，累计最高奖励400cells；如版主审阅不符合要求，或者重复可不给予评分，存在恶意行为者给予扣分；
版主会定期将战友推荐的review题目和全文链接整理并发布在1楼和2楼。谢谢大家支持！(

[ 本帖最后由 zhousjplasur 于 2007-10-7 09:18 编辑 ]

zhousjplasur

备用

zhousjplasur

备用

llecmets

题录：
Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.
Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ.

Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA. diane.krause@yale.edu

Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self-renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients. During the homing, CD34 and SCA-1 expression increases uniquely on cells that home to marrow. These adult bone marrow cells have tremendous differentiative capacity as they can also differentiate into epithelial cells of the liver, lung, GI tract, and skin. This finding may contribute to clinical treatment of genetic disease or tissue repair.

PMID: 11348593
推荐理由：
很简单，被引用次数超过1000次！

littlenapoleon

Source: CELL 116 (5): 639-648 MAR 5 2004 ;Times Cited: 255
Plasticity of adult stem cells.
Wagers AJ, Weissman IL.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. awagers@stanford.edu

Recent years have seen much excitement over the possibility that adult mammalian stem cells may be capable of differentiating across tissue lineage boundaries, and as such may represent novel, accessible, and very versatile effectors of therapeutic tissue regeneration. Yet studies proposing such "plasticity" of adult somatic stem cells remain controversial, and in general, existing evidence suggests that in vivo such unexpected transformations are exceedingly rare and in some cases can be accounted for by equally unexpected alternative explanations.

Source: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY 19: 1-22 2003 ;Times Cited: 72   
Adult stem cell plasticity: fact or artifact?
Raff M.

Medical Research Council Laboratory for Molecular Cell Biology, Cell Biology Unit, University College London, London WC1E 6BT, United Kingdom. m.raff@ucl.ac.uk

There has been unprecedented recent interest in stem cells, mainly because of the hope they offer for cell therapy. Adult stem cells are an attractive source of cells for therapy, especially in view of the recent claims that they are remarkably plastic in their developmental potential when exposed to new environments. Some of these claims have been either difficult to reproduce or shown to be misinterpretations, leaving the phenomenon of adult stem cell plasticity under a cloud. There are, however, other examples of plasticity where differentiated cells or their precursors can be reprogrammed by extracellular cues to alter their character in ways that could have important implications for cell therapy and other forms of regenerative treatment.
推荐理由：这两篇均为总结成体干细胞可塑性的综述，看看杂志，看看引用率，绝对是经典

[ 本帖最后由 zhousjplasur 于 2007-10-17 14:32 编辑 ]

anminleiryan

绝对是经典，大家都来侃侃干细胞

paulin98122

推荐一篇新综述
Stem Cells Vol. 25 No. 11 November 2007, pp. 2896 -2902
doi:10.1634/stemcells.2007-0637; www.StemCells.com

Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
Donald G. Phinney, Darwin J. Prockop
Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
  ABSTRACT：Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the capacity to generate heterotopic osseous tissue when transplanted in vivo. In recent years, MSCs or MSC-like cells have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well described. A large number of reports have also indicated that the cells possess the capacity to transdifferentiate into epithelial cells and lineages derived from the neuroectoderm. The broad developmental plasticity of MSCs was originally thought to contribute to their demonstrated efficacy in a wide variety of experimental animal models of disease as well as in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for transdifferentiation in tissue repair. Herein, we critically evaluate the literature describing the plasticity of MSCs and offer insight into how the molecular and functional heterogeneity of this cell population, which reflects the complexity of marrow stroma as an organ system, may confound interpretation of their transdifferentiation potential. Additionally, we argue that this heterogeneity also provides a basis for the broad therapeutic efficacy of MSCs.
推荐理由:作者对MSCs的横向分化及在组织修复中的作用提出了新的观点

paulin98122

Stem Cells. 2007 Nov;25(11):2739-49. Epub 2007 Jul 26.  
Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.
Chamberlain G, Fox J, Ashton B, Middleton J.
Leopold Muller Arthritis Research Centre, School of Medicine, Keele University, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shrops SY10 7AG, UK.
MSCs are nonhematopoietic stromal cells that are capable of differentiating into, and contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon, and adipose. MSCs are rare in bone marrow, representing approximately 1 in 10,000 nucleated cells. Although not immortal, they have the ability to expand manyfold in culture while retaining their growth and multilineage potential. MSCs are identified by the expression of many molecules including CD105 (SH2) and CD73 (SH3/4) and are negative for the hematopoietic markers CD34, CD45, and CD14. The properties of MSCs make these cells potentially ideal candidates for tissue engineering. It has been shown that MSCs, when transplanted systemically, are able to migrate to sites of injury in animals, suggesting that MSCs possess migratory capacity. However, the mechanisms underlying the migration of these cells remain unclear. Chemokine receptors and their ligands and adhesion molecules play an important role in tissue-specific homing of leukocytes and have also been implicated in trafficking of hematopoietic precursors into and through tissue. Several studies have reported the functional expression of various chemokine receptors and adhesion molecules on human MSCs. Harnessing the migratory potential of MSCs by modulating their chemokine-chemokine receptor interactions may be a powerful way to increase their ability to correct inherited disorders of mesenchymal tissues or facilitate tissue repair in vivo. The current review describes what is known about MSCs and their capacity to home to tissues together with the associated molecular mechanisms involving chemokine receptors and adhesion molecules.
PMID: 17656645 [PubMed - in process]
推荐理由:探讨MSCs迁移机制

llecmets

Journal: Development 135, 193-205 (2008)
Title:Islet1 cardiovascular progenitors: a single source for heart lineages?
Author:Karl-Ludwig Laugwitz1,2,*, Alessandra Moretti1,2,*, Leslie Caron1, Atsushi Nakano1 and Kenneth R. Chien1,3,*
Abstract:The creation of regenerative stem cell therapies for heart disease requires that we understand the molecular mechanisms that govern the fates and differentiation of the diverse muscle and non-muscle cell lineages of the heart. Recently, different cardiac cell types have been reported to arise from a common, multipotent Islet1 (Isl1)-positive progenitor, suggesting that a clonal model of heart lineage diversification might occur that is analogous to hematopoiesis. The ability to isolate, renew and differentiate Isl1(+) precursors from postnatal and embryonic hearts and from embryonic stem cells provides a powerful cell-based system for characterizing the signaling pathways that control cardiovascular progenitor formation, renewal, lineage specification and conversion to specific differentiated progeny.
Reasons for recommendation:最新的关于心血管干细胞来源问题的综述，文章围绕Islet1这个早期心血管干细胞标志来讲述心血管发育过程中Islet1阳性（或一过性表达过）细胞对心血管的核心作用
full text:

[ 本帖最后由 llecmets 于 2007-12-26 20:10 编辑 ]

jifeng3074

基质干细胞老化的综述

题目Mesenchymal stem cell aging
作者Christine Fehrer, Gu¨nter Lepperdinger*
出版社　Experimental Gerontology
年, 卷(期), 起止页码　　40 (2005) 926–930Abstract
Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique
abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain
and control quantity and quality of stem cells within a given pool. Otherwise, when something goes awry within a stem cell, it is likely to
have far-reaching effects.
Mesenchymal stem cells (MSC) derived from various sources such as bone marrow or fat have been expanded in culture and differentiated
in vitro into several lineages such as adipocytes, osteocytes or chondrocytes. In particular, aged human MSC show a decline in differentiation
potential as well as in proliferation rate. The latter most likely reflects the fact that aged MSC suffer from eroded telomeres. Besides the
individual age of the cell, stem and progenitor cell functions are influenced by the cellular environment, i.e. the niche and the architecture of
the tissue, they reside in. This contribution reviews current knowledge about MSC aging (in vitro or in vivo), and respective difficulties for
tissue engineering and stem cell therapy.

推荐理由　　本文从基质细胞的特性和老化两方面进行了详细论述，可从中学到好多基础知识，并能找到相关知识出处啊

[ 本帖最后由 jifeng3074 于 2008-1-7 02:19 编辑 ]

hbzcs

题目:Cell Delivery Mechanisms for Tissue Repair

作者avid J. Mooney1, and Herman Vandenburgh
出版社　 Cell Stem Cell
年, 卷(期), 起止页码　　 2, March 2008 205-213
摘要: Many cell populations, derived from both adult tissues and embryonic stem cells, show promise for the treatment of a variety of diseases. Although the major effort in stem cell therapies in the past has been identifying potentially therapeutic cells, it is now clear that developing systems to deliver these cells and promote their efficient engraftment will provide an equally challenging task. More sophisticated pretransplantation manipulations and material carriers may dramatically improve the survival, engraftment, and fate control of transplanted stem cells and their ultimate clinical utility.

推荐理由　　本文是关于组织修复的细胞分化机制最新进展,值得一读!

biowx

很多不错的文章，但是为什么要限制呢