成干体内定向分化
体内定向分化是个不错的方向，很有应用前景
Nature Neuroscience 11, 888 - 893 (2008)
Published online: 29 June 2008 | doi:10.1038/nn.2148
Directed differentiation of hippocampal stem/progenitor cells in the adult brain
Sebastian Jessberger1,2, Nicolas Toni1, Gregory D Clemenson Jr1, Jasodhara Ray1 & Fred H Gage1
Abstract
Adult neurogenesis is a lifelong feature of brain plasticity; however, the potency of adult neural stem/progenitor cells in vivo remains unclear. We found that retrovirus-mediated overexpression of a single gene, the bHLH transcription factor Ascl1, redirected the fate of the proliferating adult hippocampal stem/progenitor (AHP) progeny and lead to the exclusive generation of cells of the oligodendrocytic lineage at the expense of newborn neurons, demonstrating that AHPs in the adult mouse brain are not irrevocably specified in vivo. These data indicate that AHPs have substantial plasticity, which might have important implications for the potential use of endogenous AHPs in neurological disease.
